Background: Many plant secondary metabolites (PSMs) were shown to intercalate into DNA helix or interact with DNA grooves.This may influence histone-DNA interactions changeing chromatin structure and genome functioning.Methods: Nucleosome stability and linker histone H1.2, H1.4 and H1.5 localizations were studied in HeLa cells after the treatment w
With the improvement of industrial requirements for the quality of cold rolled strips, flatness has become one of the most important indicators for measuring the quality of cold rolled strips.In this paper, the strip production data of a 1250 mm tandem cold mill in a steel plant is modeled by an improved deep neural network (the improved DNN) to im
Junya Itou, Masafumi Itoh, Umito Kuwashima, Ken Okazaki Department of Orthopaedic Surgery, Tokyo Women’s Medical University, Tokyo, Shinjuku-ku 162-8666, JapanCorrespondence: Ken OkazakiDepartment of Orthopaedic Surgery, Tokyo Women’s Medical University, 8-1 Kawada-Cho, Tokyo, Shinjuku-ku 162-8666, JapanTel +81-3-3353-8111Fax +81-3-5269
Background and objectives: This article highlights the relationship between metabolic syndrome and cardiovascular disease, providing a comprehensive overview of its risk factors and prevalence.Metabolic syndrome, characterized by a cluster of interconnected risk factors, significantly increases the risk of developing cardiovascular disease and type
Dimethyl fumarate (DMF) is a first-line prodrug for the treatment of relapsing-remitting multiple sclerosis (RRMS) that is completely metabolized to monomethyl fumarate (MMF), the active metabolite, before reaching the systemic circulation.Its metabolism has been proposed to be Vacuum Cloth Filter due to ubiquitous esterases in the intestines and o